By Robert M. Williams
This publication provides the abstracts of the 19th overseas Congress of Heterocyclic Chemistry (19th ICHC) held in castle Collins, Colorado, 10-15th August 2003 and gives the reader with a topical accomplished reference resource protecting the most recent advancements within the heterocycles region. every one lecture from the nineteenth ICHC is gifted as a one web page summary containing a textual precis of the lecture, together with references, figures and call info of the author(s).
Papers are divided into the subsequent sections: heterocyclic average items, heterocycles in natural synthesis, bioactive heterocycles, heterocyclic fabrics &related subject matters, heterocyclic prescription drugs.
The publication of abstracts presents a topical reference resource protecting the most recent advancements within the heterocyles quarter
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Extra info for 19th International Congress on Heterocyclic Chemistry. Book of Abstracts
Therein. 1. 2. 45 ll-IL-7 Progress towards the Synthesis of Purpuromycin and Nigerone Marisa C . Kozlowski*, Stephen P. Waters, Evan S. DiVirgilio, and Carol A. Mulrooney Department of Chemistry, University ofPennsylvania Fort Collins, Colorado 80523 The rubromycin group of antitumor antibiotic natural products share an unusual bisphenolic spiroketal motif which arrays naphthazarin and isocoumarin groups orthogonal to one another as illustrated below in purpuromycin. Phenyl isocyanate initiates a key one-pot nitrile oxide formationl[3+2] cycloaddition sequence to unite the two fragments of purpuromycin in highly a convergent manner.
Kubo, T. Hayashi, J. Am. Chern. , 1991, 113,1417. b) O. Loiseleur, P. Meier and A. Pfaltz, Angew. Chem. Int. Ed. Engl. 1996, 35, 200. 43 ll-IL-5 Chiral Dipyridylphosphines and their Application in Catalytic Asymmetric Hydrogenation Reactions ling Wu, Cheng Chao Pai, and Albert S. C. Chan* Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
2002,41, 899-952. 2. , Tetrahedron Lett. 1987,28, 3489-3492. 3. , Supramolecular Chem. 2000,12,97-100. it Azolotetrazinones systems have attracted remarkable attention due to the outstanding antineoplastic activity shown by two imidazotetrazinone derivatives, mitozolomide 1 and temozolomide 2. Mitozolomide is the first azolotetrazine derivative to show excellent activity against a wide range of xenograft tumors,[ 1] but in the phase II clinical trials, its clinical use was compromised because of a deep platelet damage.