By Pierre Hainaut, Klas G. Wiman
P53 has emerged as a key tumor suppressor and critical aim for novel melanoma treatment. This publication, written via world-leading p53 researchers together with lots of those that have formed the sector over the last 25 years, offers special insights into the growth of the sector and the customers for larger melanoma analysis and remedy sooner or later.
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Extra info for 25 Years of P53 Research
Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomalstress checkpoint. Molecular and Cellular Biology, 2003. 23: 8902-8912. 1. H. , Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes and Development, 2000. 14: 981-993. , Piwnica-Worms H. Disruption r of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proceedings of the National Academy of Sciences USA, 2002.
Ott J. The p53MH algorithm and its application in detecting p53-responsive genes. Proceedings of the National Academy of Sciences USA, 2002. 99: 8467-8472. C. p53 mutations in human cancers. Science, 1991. 253: 49-53. , Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. , 1997. 420: 25-27. , Distinct p53-mediated G1/S checkpoint responses in two NIH3T3 subclone cells following treatment with DNAdamaging agents. Oncogene, 1996. 13: 625-632. A. Tumor spectrum analysis in p53- deficient mice.
G. ), 25 Years of p53 Research, 27-51. © 2005 Springer. Printed in the Netherlands. 28 Chapter 2 R248 R273 R175 G245 R249 AD1 1 20 AD2 40 R282 PXXP 60 TETRA 90 97 100 300 320 360 363 393 Figure 1. fr/p53). Indicated are the N-terminal activation domains (AD1, AD2), the proline rich region (PXXP), the central core sequence specific DNA binding domain (DNA BINDING CORE), the tetramerization domain (TETRA) and the C-terminal sequence non-specific nucleic acid binding region (BASIC). TRANSACTIVATION DOMAIN The first 100 amino acids of p53 contain two transactivation domains, a proline-rich domain and a nuclear export signal.