By J W Hendry
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Interleukin 7 (IL-7) was once stumbled on in 1988 as an element that promotes the expansion of murine В mobile precursors. IL-7 is a single-chain protein of 25kDa produced predominantly by means of epithelial cells, specially keratino-cytes and thymic epithelial cells. It performs a vital, nonredundant function within the improvement of T and В cells within the mouse and of T cells in people.
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An important work of mapping genes shall be done now to shed more light upon the genetic combinations that may be at the root of the mouse’s regenerative process. There may indeed be plausible reasons of why some animals are normally incapable of regenerative growth. First, the initial phase may fail to produce a blastema because of either an inadequate signal or an inability of the cells to respond to an adequate signal by dedifferentiation. If an adequate blastema was formed, the second-phase informational signal might be missing or inadequate to produce the subsequent patterning, redifferentiation, and growth.
Hueck, Martin Haas, Rita Finones, Jane Frimodig, and David A. Gough Enhanced Cardiac Differentiation of Mouse Embryonic Stem Cells by Electrical Stimulation . . . . . . . . . . . . Paul R. Bidez III, J. Yasha Kresh, Yen Wei, and Peter I. Lelkes The Therapeutic Potential of ES-Derived Haematopoietic Cells . . . Sabrina Gordon-Keylock and Lesley Forrester 41 61 79 119 143 Genetic Modification of Human Embryonic and Induced Pluripotent Stem Cells: Viral and Non-viral Approaches . . .
Hwal (Matthew) Suh Neural Stem Cells: From Cell Fate and Metabolic Monitoring Toward Clinical Applications . . . . . . . . . . . . Jan Pruszak, Máté Döbrössy, Jochen Kieninger, Kuppusamy Aravindalochanan, Gerald A. Urban, and Guido Nikkhah 403 417 435 Contents Adult Stem Cells in Drug Discovery . . . . . . . . . . Stefan Golz, Andreas Geerts, and Andreas Wilmen xxxiii 457 Embryonic Stem Cells as a Tool for Drug Screening and Toxicity Testing 473 Bernd Denecke and Silke Schwengberg Embryonic Stem Cells: A Biological Tool to Translate the Mechanisms of Heart Development .