By David A Bender(auth.)
Amino Acid Metabolism, 3rd Edition covers all facets of the biochemistry and dietary biochemistry of the amino acids. beginning with an summary of nitrogen fixation and the incorporation of inorganic nitrogen into amino acids, the booklet then info different significant nitrogenous compounds in micro-organisms, crops and animals. Contents comprise a dialogue of the catabolism of amino acids and different nitrogenous compounds in animals, and the microbiological reactions occupied with unlock of nitrogen fuel again into the ambience. Mammalian (mainly human) protein and amino acid requisites are thought of intimately, and the equipment which are used to figure out them.
Chapters examine person amino acids, grouped in line with their metabolic starting place, and discussing their biosynthesis (in vegetation and micro-organisms for people that are nutritional necessities for human beings), significant metabolic roles (mainly in human metabolism) and catabolism (again frequently in human metabolism). there's additionally dialogue of regulatory mechanisms for most of these metabolic pathways, and of metabolic and genetic ailments affecting the (human) metabolism of amino acids.
Throughout the booklet the emphasis is at the dietary value of amino acids, integration and keep an eye on of metabolism and metabolic and different disturbances of relevance to human biochemistry and health.
- Completely revised variation of this accomplished textual content protecting all of the newest findings in amino acid metabolism research
- Written via an expert within the box
- Covers new advances in structural biology
- Clear illustrations of all constructions and metabolic pathways
- Full record of suggested extra studying for every bankruptcy and bibliography of papers mentioned within the text
Chapter 1 Nitrogen Metabolism (pages 1–65):
Chapter 2 Nitrogen stability and Protein Turnover – Protein and Amino Acids in Human foodstuff (pages 67–104):
Chapter three The function of nutrition B6 in Amino Acid Metabolism (pages 105–128):
Chapter four Glycine, Serine and the One?Carbon Pool (pages 129–155):
Chapter five Amino Acids Synthesized from Glutamate: Glutamine, Proline, Ornithine, Citrulline and Arginine (pages 157–223):
Chapter 6 Amino Acids Synthesized from Aspartate: Lysine, Methionine (and Cysteine), Threonine and Isoleucine (pages 225–277):
Chapter 7 The Branched?Chain Amino Acids: Leucine, Isoleucine and Valine (pages 279–303):
Chapter eight Histidine (pages 305–322):
Chapter nine The fragrant Amino Acids: Phenylalanine, Tyrosine and Tryptophan (pages 323–376):
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Extra info for Amino Acid Metabolism, Third Edition
It acts as an antioxidant, forming allantoin non-enzymically by reaction with reactive oxygen species, and it also stimulates the innate immune system. , 2009). The active secretion of uric acid in the distal renal tubule is inhibited by lactic and other acids. Conditions that are associated with persistent lactic acidosis (such as some types of glycogen storage disease) lead to impaired excretion of uric acid and the early development of gout. Premenopausally, women are less at risk of gout than are men, although this gender difference is lost after the menopause.
There is evidence that oestrogens lower serum uric acid and, while some studies show increased uric acid excretion in response to oestrogen administration, others do not. 10), which results in less utilization of PRPP and, hence, an increased concentration which overcomes the inhibition of PRPP amidotransferase by its end products. 2, genetic defects that result in increased activity of PRPP synthetase also lead to increased purine synthesis and catabolism, and hence may be a cause of gout. Large amounts of fructose can increase uric acid production because the phosphorylation of fructose to fructose 1-phosphate is unregulated, leading to depletion of intracellular inorganic phosphate, accumulation of ADP and AMP and increased catabolism via adenosine deaminase.
The reaction of glutamine synthetase is one of those in which it is easy to explain the role of ATP in an endothermic reaction. Although, overall, the amidation of glutamate is linked to hydrolysis of ATP to ADP and inorganic phosphate, the reaction proceeds by way of intermediate phosphorylation of glutamate to γ-glutamyl-phosphate. 3). 5) is used to synthesize glutamate and glutamine for transport to the liver. Liver cells adjacent to the central vein, which drains the liver into the main venous circulation, have active glutamate dehydrogenase and glutamine synthetase, so as to ensure that little or no ammonium enters the bloodstream.