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Celll (2000) 5:513-522 33. Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itie A, Wakeham A, Shahinian A, Henzel WJ, Elia AJ, Shillinglaw W, Mak TW, Cao Z, and Yeh WC, Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaBdependent gene transcription. EMBO J. (2000) 19:4976-4985 34. Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue JI, Uematsu S, Takeuchi O, and Akira S, Interferon-alpha induction through Tolllike receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.

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