Download Cytotoxic Cells: Recognition, Effector Function, Generation, by Michail V. Sitkovsky, Pierre A. Henkart PDF

By Michail V. Sitkovsky, Pierre A. Henkart

Our motivation for placing jointly this e-book used to be the necessity for a unmarried resource reference which may be used as an advent to cell-mediated cytotoxicity for rookies to this box, akin to scholars and fellows starting paintings in our laboratories. at this time no such ebook is offered, and we felt that it'd be invaluable as a instructing software and as a fashion of conveying our enthusiasm approximately contemporary growth within the cytotoxicity box to our colleagues in allied parts. It was once with a few hesitation that we approached our colleagues with the thought for this e-book, and we have been happy to discover them very supportive of the belief and keen to take part. We proposal it very important to increase the scope of the ebook to incorporate old, molecular, cellphone organic, and scientific facets of cell-mediated cytotoxicity. To our wisdom this is often the 1st ebook on cell-mediated cytotoxicity with any such extensive scope. traditionally, reviews on mobile cytotoxicity have been a part of mobile immunology from its beginning. One improvement of great import used to be the appearance of the fifty one Cr assay, which allowed this arm of the immune reaction to be measured simply and quantitatively. hence, a readout of this effector pathway is out there inside of a number of hours; different immune effector features can take days or perhaps longer to assay, and the assays are usually much less quantitative.

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Additional resources for Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods

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The films generally allowed several hours of postcontact observation, long enough that lysis would have been seen had the target been pro- 26 ERIC MARTZ grammed to lyse (Martz, 1977). , less talin accumulation, weaker adhesion, or orientation of the MTOC towards another target). Taken at face value, these cases indicate that a type 4 exchange can occur before a target has been programmed to lyse. Balk's work, mentioned below, supports the same conclusion. Three other time-lapse studies, although offering no quantitative data, are consistent with Sanderson's conclusions.

At least two studies have directly addressed the role of bystander adhesion. In one,bystanders were "glued" to CTL with wheat germ agglutinin or antithymocyte serum (which engaged Fc receptor on the targets employed). The bystanders were spared despite being glued to CTL which were simultaneously killing cognate targets (Wei and Lindquist, \981). In another study, the bystanders were T-helper cells which recognized alloantigens on the CTL, thus producing an adhesion active from the bystander side.

At least two studies have directly addressed the role of bystander adhesion. In one,bystanders were "glued" to CTL with wheat germ agglutinin or antithymocyte serum (which engaged Fc receptor on the targets employed). The bystanders were spared despite being glued to CTL which were simultaneously killing cognate targets (Wei and Lindquist, \981). In another study, the bystanders were T-helper cells which recognized alloantigens on the CTL, thus producing an adhesion active from the bystander side.

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